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Criteria to qualify for study: Drug used in study:
  • Untreated
  • Serum M protein must be at least 0.5 g/dL
  • Urine M proteint must be at least 200 mg/24hr
  • A difference between the involved IG free light chain and uninvolved light chain of at least 5 mg/dL AND abnormal serum IG kappa lambda free light chain ratio
  • ANC must be at least 1000
  • PLT must be at least 75

CBCI-248 Karmanos 2011-155

Phase I Study of Pomalidomide, Bortezomib, and Dexamethasone (PVD) as First-Line Treatment of AL Amyloidosis or Light Chain Deposition Disease