MDS

Criteria to qualify for study: Drug used in study:
  • MDS IPSS High-Risk or Intermediate 2
  • Intolerant of Hypomethylating Agents or not have responded to 4 cycles of decitabine or 6 cycles of azacidine
  • Progressed after initation of HMA

HEMREF 48 - H3B-8800-101 H3 Biomedicine and Eisai

An Open-label, Multicenter Phase 1 trial to evaluate the safety, Pharmacokynetics and Pharmacodynamic of splicing modulator H3B-8800 for subjects with Myelodysplastic Syndromes.