Non-Hodgkin Lymphoma

Criteria to qualify for study: Drug used in study:
  • B-Cell NHL, CLL-SLL, Waldenstrom’s Macroglobulinemia, Richter’s transformation, Follicular Lymphoma, MCL, MZL

HR 52

A Phase 1 Dose Escalation Study to investigate the safety, pharmacokinetics, pharmacodynamics, and clinical activity of ARQ 531 in selected subjects with Relapsed or Refractory Hematologic Malignancies.

Criteria to qualify for study: Drug used in study:
  • Relapsed / Refractory
  • 2 part, multicenter, open label, phase 1a/1b study of TTI-622 in patients with advanced relapsed or refractory lymphoma and multiple myeloma

HR 56 TTI-622-01

A Phase 1a/1b dose escalation and expansion trial of TTI-622 in patients with Advanced Relapsed or Refractory Lymphoma or Myeloma.

Criteria to qualify for study: Drug used in study:
  • Relapsed of refractory multiple myeloma or relapsed of refractory B-Cell NHL after at least 2 prior regimens.

HR 59

A phase 1a/1b open label, multicenter study evaluating the safety and pharmacokinetics of Tiragolumab as a single agent and in combination with Daratumumab in patients with relapsed or refractory Multiple Myeloma, and as a single agent and in combination with Rituximab in patients with relapsed of refractory B-Cell Non Hodgkin Lymphoma.

Criteria to qualify for study: Drug used in study:
  • Confirmed NHL, iNHL, or ALL; evidence of CD19 expression.

HR 62

A Phase 1/2 Open-Label, Clinical Trial of TC-110 T Cells in adults with Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) or Acute Lymphoblastic Leukemia.

Criteria to qualify for study: Drug used in study:
  • ECOG<3, LVET, >50%

HR 64

A phase 1, open label, multicenter, dose escalation study of PRT1419 in subjects with relapsed/refractory hematological malignancies.

Criteria to qualify for study: Drug used in study:
  • At least 2 lines of prior therapies including an anthracycline and an anti-CD20 monoclonal antibody.

LYM 151

A Single-Arm, open –label phase ½ study evaluating the safety and efficacy and Cellular Kinetics/Pharmacodynamics of ALLO-501, an Anti-CD19 Allogeneic CAR-T Cell Therapy in patients with relapsed/refractory Large B-Cell and Follicular Lymphoma.

Criteria to qualify for study: Drug used in study:
  • ECOG <=2; diagnosis of classical Hodgkin Lymphoma

LMY 157

A Phase 2 front line PET-CT 2 response adapted Brentuximab Vedotin and Nivolumab incorporated and radiation free management of early stage classical Hodgkin Lymphoma (cHL)

Criteria to qualify for study: Drug used in study:
  • FL, MZL, SLL, DLBCL, HGBCL, PMBCL, MCL, or CLL; ECOG 0 or 1

LYM 166

Safety and efficacy of GEN3009 (DuoHexaBody-CD37) in relapsed or refractory B-cell Non-Hodgkin Lymphoma – A first in human, Open label, Phase 1/lla dose escalation trial with dose expansion cohorts.

Criteria to qualify for study: Drug used in study:
  • Relapsed/refractory Large B-cell Lymphoma; at least 1 measurable lesion; at least 2 lines of prior therapies including an anthracycline and an anti-CD20 monoclonal antibody

LYM 168

A Single-Arm, Open-Label, Phase 1/2 study evaluating the safety, efficacy and Cellular Kinetics/Pharmacodynamics of ALLO-501A, an Anti-CD19 Allogeneic CAR-T Cell Therapy in subjects with Relapsed/Refractory Large B-Cell Lymphoma (LBCL)

Criteria to qualify for study: Drug used in study:
  • CD20+; relapsed of refractory following anti – CD20 monoclonal antibody

LYM 171

A Phase 1/2, open label, dose escalation trial of GEN3013 in patients with relapsed, progressive or refractory B Cell Lymphoma.

Criteria to qualify for study: Drug used in study:
  • R/R CLL, SLL, WM, MCL, MZL, FL or DLBCL; ECOG 0 or 1

LYM 184

A Phase 1 dose escalation, safety and tolerability study of NX-2127, a Bruton’s Tyrosine Kinase (BTK) degrader, in adults with relapsed/refractory B-Cell malignancies.