Non-Hodgkin Lymphoma

Criteria to qualify for study: Drug used in study:
  • Now only enrolling PTCL. Must have failed 1 prior therapy and Have 1 site of measurable disease.

HR 43

A phase 1a/1b dose escalation trial of single agent TTl-621, a novel biologic targeting CD47, in subjects with relapsed of refractory hematologic malignancies.

Criteria to qualify for study: Drug used in study:
  • B-Cell NHL, CLL-SLL, Waldenstrom’s Macroglobulinemia, Richter’s transformation, Follicular Lymphoma, MCL, MZL

HR 52

A Phase 1 Dose Escalation Study to investigate the safety, pharmacokinetics, pharmacodynamics, and clinical activity of ARQ 531 in selected subjects with Relapsed or Refractory Hematologic Malignancies.

Criteria to qualify for study: Drug used in study:
  • Relapsed / Refractory
  • 2 part, multicenter, open label, phase 1a/1b study of TTI-622 in patients with advanced relapsed or refractory lymphoma and multiple myeloma

HR 56 TTI-622-01

A Phase 1a/1b dose escalation and expansion trial of TTI-622 in patients with Advanced Relapsed or Refractory Lymphoma or Myeloma.

Criteria to qualify for study: Drug used in study:
  • Relapsed of refractory multiple myeloma or relapsed of refractory B-Cell NHL after at least 2 prior regimens.

HR 59

A phase 1a/1b open label, multicenter study evaluating the safety and pharmacokinetics of Tiragolumab as a single agent and in combination with Daratumumab in patients with relapsed or refractory Multiple Myeloma, and as a single agent and in combination with Rituximab in patients with relapsed of refractory B-Cell Non Hodgkin Lymphoma.

Criteria to qualify for study: Drug used in study:
  • Confirmed NHL, iNHL, or ALL; evidence of CD19 expression.

HR 62

A Phase 1/2 Open-Label, Clinical Trial of TC-110 T Cells in adults with Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) or Acute Lymphoblastic Leukemia.

Criteria to qualify for study: Drug used in study:
  • Prior allogeneic HCT history or presence of CNS pathology or involvement

LYM 140

A Single Arm, Open label, multi-center Phase I/II study evaluating the safety and clinical activity of AUTO3, a CAR-T Cell treatment targeting CD19 and CD22 and consolidation with Anti-PD1 Antibody in patients with relapsed of refractory Diffuse Large B Cell Lymphoma.

Criteria to qualify for study: Drug used in study:
  • Relapsed of refractory B-Cell NHL after front line therapy.

LYM 147

Tisagenlecleucel versus standard of care in adult patients with relapsed of refractory aggressive B-CELL Non-Hodgkin Lymphoma. A randomized, open label phase lll trial (BELINDA).

Criteria to qualify for study: Drug used in study:
  • At least 2 lines of prior therapies including an anthracycline and an anti-CD20 monoclonal antibody.

LYM 151

A Single-Arm, open –label phase ½ study evaluating the safety and efficacy and Cellular Kinetics/Pharmacodynamics of ALLO-501, an Anti-CD19 Allogeneic CAR-T Cell Therapy in patients with relapsed/refractory Large B-Cell and Follicular Lymphoma.

Criteria to qualify for study: Drug used in study:
  • Eligible for first BMT after induction chemotherapy; archival tumor block for MDR testing

LYM 155

Single Arm, Phase ll Study of Acalabrutinib as Post-Autologous Blood or Marrow transplant (BMT) maintenance therapy in subjects with Mantel Cell Lymphoma.

Criteria to qualify for study: Drug used in study:
  • FL, MZL, SLL, DLBCL, HGBCL, PMBCL, MCL, or CLL; ECOG 0 or 1

LYM 166

Safety and efficacy of GEN3009 (DuoHexaBody-CD37) in relapsed or refractory B-cell Non-Hodgkin Lymphoma – A first in human, Open label, Phase 1/lla dose escalation trial with dose expansion cohorts.

Criteria to qualify for study: Drug used in study:
  • Relapsed/refractory Large B-cell Lymphoma; at least 1 measurable lesion; at least 2 lines of prior therapies including an anthracycline and an anti-CD20 monoclonal antibody

LYM 168

A Single-Arm, Open-Label, Phase 1/2 study evaluating the safety, efficacy and Cellular Kinetics/Pharmacodynamics of ALLO-501A, an Anti-CD19 Allogeneic CAR-T Cell Therapy in subjects with Relapsed/Refractory Large B-Cell Lymphoma (LBCL)

Criteria to qualify for study: Drug used in study:
  • CD20+; relapsed of refractory following anti – CD20 monoclonal antibody

LYM 171

A Phase 1/2, open label, dose escalation trial of GEN3013 in patients with relapsed, progressive or refractory B Cell Lymphoma.

Criteria to qualify for study: Drug used in study:
  • Histologically documented DLBCL; no prior treatment for DLBCL; IPI of 2 to 5

LYM 172

A Phase 3, randomized, double – blind, placebo controlled, multicenter study of Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) alone versus in combination with Acalabrutinib in subjects <65 years with previously untreated non-germinal center Diffuse Large B Cell Lymphoma.